Materials such as Titanium and PEEK have been traditionally selected for orthopedic implants based on their mechanical properties. Due to the low bioactivity of their surfaces, these materials do not encourage comprehensive bone growth (osteoconductivity) onto the implant itself - a leading cause of implant failures from loosening at the device-bone interface.

The Orthobond Osteoconductive Self-Assembled Monolayer of Phosphonate (O-SAMP) Surface Modification is one molecule thick and covalently bound to the surfaces of implantable materials. Because of O-SAMP's nanometer scale, it permeates all of the interstices of the material to which it is applied, assuring total implant coverage regardless of material or texture. The O-SAMP surface treatment elicits a biological response on inorganic implants without the use of a biologic.

The Orthobond O-SAMP treatment rapidly recruits osteoblasts to the surface of the implant where they undergo enhanced proliferation, differentiate into bone and mineralize the surface. This is the first step in the biologic process of attaining adhesion between implants and the host bone, with the final result being direct integration. This surface modification increases the fixation between the implant and the bone at a rapid rate.

For more information, download our white paper on O-SAMP.